Acute Leukemias IX: Basic Research, Experimental Approaches by T. Haferlach, C. Schoch, W. Hiddemann (auth.), Prof. Dr. PDF

By T. Haferlach, C. Schoch, W. Hiddemann (auth.), Prof. Dr. med. Wolfgang Hiddemann, Prof. Dr. Dr. med. phil. Torsten Haferlach, Dr. med. Michael Unterhalt, Prof. Dr. med. Thomas Büchner, Prof. Dr. med. Jörg Ritter (eds.)

ISBN-10: 3540439714

ISBN-13: 9783540439714

ISBN-10: 3642593585

ISBN-13: 9783642593581

ISBN-10: 3642639496

ISBN-13: 9783642639494

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Additional info for Acute Leukemias IX: Basic Research, Experimental Approaches and Novel Therapies

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A. (1995). The t(12;21) of acute lymphoblastic leukemia results in a tel-AMLl gene fusion, Blood 85, 3662-70. Rubnitz, I. , Downing, J. , and Pui, C. H. (1999). Significance of the TEL-AML fusion gene in childhood AML [letter], Leukemia 13, 1470-1. Westendorf, J. , Yamamoto, C. , Downing, J. , Selsted, M. , and Hiebert, S. W. (1998). The t( 8;21) fusion product, AML-l/ETO, associates with C/EBPa, inhibits C/EBPa-dependent transcription, and blocks granuloctyic differentiation, Mol Cell BioI 18, 322-333.

W. (1995). The t(8;21) fusion protein interferes with AML-IBdependent transcriptional activation, Molecular & Cellular Biology 15, 1974-82. , and Ohki, M. (1993). The t(8;21) translocation in acute myeloid leukemia results in production of an AMLl-MTG8 fusion transcript, Embo I 12,2715-2721. , and Ohki, M. (1991). t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AMLl, Proc Nat! Acad Sci USA 88, 10431-10434. Romana, S. , and Bernard, 0.

1996; Matsuo et al. 1997; Van Dongen and Wolvers-Tettero 1991). Results and Discussion A human leukemia cell line, named MUTZ-5, was established from the peripheral blood of a 26-year-old man with BCP-ALL at relapse in 1998. The simultaneous sister cell lines MUTZ-6 and MUTZ-7 which were derived independently but from the same original peripheral blood cell sample showed similar or identical features. Pertinent cell culture characteristics of MUTZ-5 are summarized in Table 2. MUTZ-5 cells were found to be negative for Epstein-Barr virus (EBV) and other viruses (Table 2) and also for mycoplasma.

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Acute Leukemias IX: Basic Research, Experimental Approaches and Novel Therapies by T. Haferlach, C. Schoch, W. Hiddemann (auth.), Prof. Dr. med. Wolfgang Hiddemann, Prof. Dr. Dr. med. phil. Torsten Haferlach, Dr. med. Michael Unterhalt, Prof. Dr. med. Thomas Büchner, Prof. Dr. med. Jörg Ritter (eds.)


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