ADAMTS13: Biology and Disease by George M. Rodgers PDF

By George M. Rodgers

ISBN-10: 3319087169

ISBN-13: 9783319087160

ISBN-10: 3319087177

ISBN-13: 9783319087177

This complete quantity discusses the protease ADAMTS13, summarizing the present prestige of simple and scientific learn. The 9 authoritative chapters start with a historic standpoint via exploration of the biochemistry and structure-function relationships of ADAMTS13 in addition to its basic functionality in hemostasis (cleavage of von Willebrand factor). rising learn topics for ADAMTS13 are lined, together with its power position in angiogenesis and different features of telephone biology. extra subject matters contain laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and purchased ADAMTS13 deficiency. A bankruptcy on similar thrombotic microangiopathic (TMA) issues examines the variations among TMAs linked to ADAMTS13 deficiency and people no longer linked to ADAMTS13 deficiency. a last bankruptcy experiences the initial info on rising elements of ADAMTS13, similar to the prestige of recombinant ADAMTS13 items and their power utility.

Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and disorder is an important source for medical hematologists, transfusion medication physicians, and researchers attracted to hemostasis, vascular biology, biochemistry, and metalloproteases.

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Mittaz L, Russell DL, Wilson T, Brasted M, Tkalcevic J, Salamonsen LA, Hertzog PJ, Pritchard MA. Adamts-1 is essential for the development and function of the urogenital system. Biol Reprod. 2004;70(4):1096–105. 66. Brown HM, Dunning KR, Robker RL, Boerboom D, Pritchard M, Lane M, Russell DL. ADAMTS1 cleavage of versican mediates essential structural remodeling of the ovarian follicle and cumulus-oocyte matrix during ovulation in mice. Biol Reprod. 2010;83(4): 549–57. 084434. 084434. Epub 2010/07/02.

Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation. Dev Dyn. 2012;241(2):303–14. 23716. 61. Lee NV, Rodriguez-Manzaneque JC, Thai SN, Twal WO, Luque A, Lyons KM, Argraves WS, Iruela-Arispe ML. Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1. J Biol Chem. 2005;280:34796–804. 62. Hashimoto G, Shimoda M, Okada Y. ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan.

Elegans, fruit fly D. melanogaster, and sea squirt Ciona intestinalis, allowed determination of the evolutionary relationships within the family [8]. This phylogenetic analysis suggested that mammalian ADAMTS proteases arose from duplication and divergence of a small number of related proteases encoded by ancestral genomes [8]. As a consequence of gene duplication, most ADAMTS proteases (ADAMTS13 as exception) have one or more homologous proteases (Fig. 1), and thus the mammalian ADAMTS family is divided into several subfamilies [8, 9].

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ADAMTS13: Biology and Disease by George M. Rodgers

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