By Wojciech Gorczyca
This huge reference protecting neoplastic hematopathology comprises over 500 color illustrations depicting hematopoietic tumors concerning lymph nodes, spleen, bone marrow, and mostly affected extranodal organs, with exact emphasis at the differential analysis. It discusses easy medical, prognostic, morphologic and phenotypic information, with a number of tables summarizing the phenotypic profiles of the commonest hematologic tumors. an enormous function of this e-book is an method of hematologic tumors in line with the WHO type, with appropriate examples and emphasis at the Most worthy morphologic and immunophenotypic beneficial properties utilized in diagnosis.It may be a useful reference for all working towards hematologists, oncologists and pathologists.
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Extra resources for An Atlas of Differential Diagnosis in Neoplastic Hematopathology
19 Flow cytometry immunophenotyping—CD4:CD8 ratio. Apart from evaluation of pan-T antigens, the CD4:CD8 ratio is a very useful parameter in flow cytometric analysis of hematolymphoid lesions (A–D). Predominance of either CD4+ or CD8+ cells, dual expression of CD4/CD8 or lack of both CD4/CD8, although not completely diagnostic, may indicate malignancy (including both mature/post-thymic and precursor lesions). Classical Hodgkin lymphoma and NLPHL are often associated with an increased CD4:CD8 ratio (A).
5 summarizes flow cytometric criteria to identify abnormal T-cell population. Loss of one pan-T antigen is present in ~40% of peripheral (mature/post-thymic) Tcell neoplasms. CD7 is most commonly absent (~42%), followed by CD3 (~26%), CD5 (~22%) and CD2 (~11%). Lack of two pan-T antigens is present in ~16%, three pan-T antigens in ~7% and all four pan-T antigens in 2% of cases. Diminished expression of pan-T antigens is less specific for T-cell neoplasms than complete lack of the expression. , diffuse large B-cell lymphoma, Hodgkin lymphoma).
Gating on cells with bright CD20 expression and slightly higher forward scatter (E) yields monoclonal lambda+ population (arrow, histograms on the right). 13 Flow cytometry immunophenotyping—gating strategy 24 Introduction 25 based on the intensity of CD20 expression (see text for details) Prognostic markers Determination of the expression of ZAP70 and/or CD38 by FC can serve as a prognostic marker in patients with B-chronic lymphocytic leukemia (B-CLL). Naive-type CLL is more often positive for CD38 and/or ZAP70 and is associated with a poorer prognosis than the IgH-rearranged type of CLL, which is more often negative for these markers35,36.
An Atlas of Differential Diagnosis in Neoplastic Hematopathology by Wojciech Gorczyca