Analyzing T Cell Responses: How to analyze cellular immune by Dirk Nagorsen, Francesco M. Marincola PDF

By Dirk Nagorsen, Francesco M. Marincola

ISBN-10: 1402036221

ISBN-13: 9781402036224

ISBN-10: 140203623X

ISBN-13: 9781402036231

This publication experiences, describes, categorizes and offers a serious overview of all assays which have been used for the tracking of antigen-specific immune responses. specifically, it emphasizes an international method of the research of T telephone mediated target/host interactions on the systemic and the peripheral point while such interactions are meant to ensue. additionally, the instruments defined right here should be applied for the hunt of surrogate biomarkers predictive of therapy responsiveness and/or medical final result which are of curiosity to the biotechnology undefined. intimately, this e-book presents an summary of antigen-specific immune biology in human types of tumor and viral illness, discusses modulation of such responses via immune get away and offers mobile assays (cytoxicity, proliferation, cytokine construction utilizing ELISPOT, intracellular staining or cytometric overview, detection of antigen-specific T cells with tetrameric HLA/epitope complexes or MHC-IG dimers, T phone receptor research, evaluation of T mobile receptor/HLA interactions utilizing peptide/HLA-Green Fluorescent Protein complexes incorporation) and molecular assays together with quantitative real-time PCR and gene profiling for assessment of systemic and peripheral immune responses. "This ebook represents the 1st entire description and overview of an important assays applied to observe immune responses opposed to tumor linked antigens. each one bankruptcy, ready by way of best investigators in tumor immunology and immunotherapy, info a selected immune subject or analytical strategy. in particular adapted to the wishes of scientific researchers, easy scientist investigators, and biotechnology innovators, this booklet presents info that's either sufficiently targeted and eloquently succinct. All discussions are substantiated with a accomplished literature evaluation. The categorization and association of those sections is such that you can still both pursue the full ebook or speedy locate valuable details on a particular assay or proposal of curiosity. a close description of the equipment used in the id of tumor linked antigens is complemented via large lists of HLA classification I, and sophistication II constrained antigens. This e-book additionally addresses the basic subject of tumor cells?€™ skill to avoid immune acceptance and destruction. the capability mechanisms in regards to the disparity among the patients?€™ immunological and scientific reaction following immunization are reviewed. Importantly, capability healing options to beat the immune break out mechanisms were mentioned. In precis, examining T mobilephone Responses presents the main gigantic and large evaluation of immune response-monitoring innovations on hand so far. This considerable info is successfully conveyed in a concise demeanour acceptable for either starting investigators and skilled researchers."

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Extra resources for Analyzing T Cell Responses: How to analyze cellular immune responses against tumor associated antigens

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Salazar-Onfray F, Nakazawa T, Chhajlani V, et al. Synthetic peptides derived from the melanocyte-stimulating hormone receptor MC1R can stimulate HLA-A2-restricted cytotoxic T lymphocytes that recognize naturally processed peptides on human melanoma cells. Cancer Res. 1997;57(19):4348-4355. 137. Correale P, Walmsley K, Nieroda C, et al. In vitro generation of human cytotoxic T lymphocytes specific for peptides derived from prostate-specific antigen. J Natl Cancer Inst. Feb 19 1997;89(4):293-300.

139. Khong HT, Rosenberg SA. The Waardenburg Syndrome Type 4 Gene, SOX10, Is a Novel Tumor- associated Antigen Identified in a Patient with a Dramatic Response to Immunotherapy. Cancer Res. 2002;62(11):3020-3023. 140. Parkhurst MR, Fitzgerald EB, Southwood S, Sette A, Rosenberg SA, Kawakami Y. Identification of a shared HLA-A*0201-restricted T-cell epitope from the melanoma antigen tyrosinase-related protein 2 (TRP2). Cancer Res. 1998;58(21):4895-4901. 141. Noppen C, Levy F, Burri L, et al. 1restricted epitopes from tumor-associated antigen tyrosinase-related protein-2.

57. 58. 33 histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes. J Exp Med. 1998;187(2):265-270. Wang RF, Johnston SL, Zeng G, Topalian SL, Schwartzentruber DJ, Rosenberg SA. A breast and melanoma-shared tumor antigen: T cell responses to antigenic peptides translated from different open reading frames. J Immunol. 1998;161(7):3598-3606. Jager E, Stockert E, Zidianakis Z, et al. Humoral immune responses of cancer patients against "Cancer-Testis" antigen NY-ESO-1: correlation with clinical events.

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Analyzing T Cell Responses: How to analyze cellular immune responses against tumor associated antigens by Dirk Nagorsen, Francesco M. Marincola


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