By Hubert Schrezenmeier, Andrea Bacigalupo
This publication takes account of the latest findings in laboratory examine and medical trials to supply a finished and up to date reference at the pathophysiology, epidemiology, prognosis and remedy of got and inherited aplastic anemia. in addition to supplying an in depth evaluate of the pathophysiology of the affliction, the overseas staff of authors covers all points of administration, together with the verified ways of bone marrow transplantation and immunosuppressive therapy, new ways equivalent to using hematopoietic progress elements and escalated immunosuppression, and debatable concerns akin to stem phone transplantation. additionally incorporated is a vital foreign consensus rfile on therapy, and a last part concentrates at the inherited syndrome Fanconi's anemia. particular therapy directions are given, making this the definitive source for hematologists and different clinicians eager about the administration and supportive care of sufferers with aplastic anemia. Scientists drawn to bone marrow failure also will locate this a useful reference.
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Additional info for Aplastic Anemia: Pathophysiology and Treatment
Bartley, T. , Li, Y. , Chang, M. , Nichol, J. L. and Swift, S. (1994) Identiﬁcation and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell, 77, 1117–24. Camitta, B. , Storb, R. and Thomas, E. D. (1982) Aplastic anemia: pathogenesis, diagnosis, treatment and prognosis. New England Journal of Medicine, 306, 645–50. Champlin, R. , Nimer, S. , Otte, D. H. and Golde, D. W. (1989) Treatment of refractory aplastic anemia with recombinant human granulocyte-macrophage colonystimulating factor.
A decrease in plasma EPO levels was noted in all erythroid responders. For any given degree of anemia, the plasma EPO level was lower in patients of the BMT group than in patients receiving immunosuppressive therapy. Furthermore, plasma EPO levels were inappropriately decreased in more than half of the patients who received BMT compared with iron-deﬁcient patients. Cyclosporin probably caused the decreased plasma EPO levels in BMT patients. 1. Plasma concentrations of erythropoietin (EPO) in 75 patients with aplastic anemia (AA) and 15 normal controls.
And Jacobsen, S. E. W. (1996) The ﬂt-3 ligand is a direct and potent stimulator of the growth of primitive and committed human CD34ϩ bone marrow progenitor cell in vitro. Blood, 87, 1317–25. de Sauvage, F. , Hass, P. , Spencer, S. , Malloy, B. , Gurney, A. , Spencer, S. , Cytokine abnormalities in aplastic anemia Darbonne, W. , Henzel, W. , Wong, S. , Kuang, W. , Oles, K. , Solberg, L. , Goeddel, D. V. and Eaton, D. L. (1994) Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand.
Aplastic Anemia: Pathophysiology and Treatment by Hubert Schrezenmeier, Andrea Bacigalupo