By L. Heilmeyer, H. Begemann
-Enhanced sixth version includes extra illustrations and documented figures -A ideal reference for hematological and oncological departments and the clincal labortory -Classified findings from the realm wellbeing and fitness association
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Extra resources for Atlas of Clinical Hematology
Red and white cell precursors account for most of the cells found in normal bone marrow. In addition there are variable numbers of reticulum cells, vascular and sinus endothelial cells, megakaryocytes, tissue mast cells, lymphocytic elements, plasma cells and, very rarely, osteoblasts and osteoclasts (more common in children). The earliest precursors of the red and white blood cells have a basophilic cytoplasm and are very similar to one another. As hemoglobin synthesis increases, the erythroblasts lose their basophilic cytoplasm while their nuclei undergo a characteristic structural change.
13 h). Monocyte, with a metamyelocyte at upper left (Fig. 13 c). IV Monocyte with a small nucleus and, below it, a segmented neutrophil (Fig. 13 d). Two promonocytes in a bone marrow smear (Fig. 13 e). Two promonocytes with nucleoli, and a monocyte at upper left (Fig. 13 f). Monocytes. The monocyte is an exceptionally pleomorphic blood cell ranging from 12 to 20 lm in size. Its cytoplasm often has irregular borders and stains a characteristic grayish blue. Some monocytes contain azurophilic granules much finer than those seen in lymphocytes.
As the coarse promyelocytic granules become more sparse, the typical fine neutrophilic granularity becomes predominant. The basophilic cytoplasm lightens from the nucleus outward, becoming acidophilic, while the nuclear chromatin acquires a coarser structure. Nucleoli are rarely visible. The myelocyte is the most plentiful granulocytopoietic cell type found in the bone marrow. As maturation proceeds, the nuclear chromatin becomes even coarser and more dense. The nucleus becomes indented or horseshoe-shaped, while the cytoplasm and granules remain essentially the same as in mature myelocytes.
Atlas of Clinical Hematology by L. Heilmeyer, H. Begemann