By H. Oberpichler-Schwenk (auth.), Prof. Dr. S. Hoyer, Dr. D. Müller, Dr. K. Plaschke (eds.)
Although age has been well-known as a threat issue for late-onset dementia of Alzheimer sort, its etiology is unknown as but. a number of age-related metabolic abnormalities may perhaps hence turn into very important for the pathogenesis of the late-onset shape. reports on the cellular/molecular point in mind tissue are attainable submit mortem, yet lack details at the starting of the illness. during this complement, diverse methods are handled how you can set off structural and/or metabolic abnormalities in appropriate cellphone cultures, in mind slices and in experimental animals, and the way behavioral adjustments parallel the metabolic variations.
Read or Download Cell and Animal Models in Aging and Dementia Research PDF
Similar research books
The Japan organization of Simulation & Gaming (JASAG) and the technological know-how Council of Japan (SCJ) hosted ISAGA 2003, the thirty fourth annual convention of the foreign Simulation and Gaming organization (ISAGA), at Kazusa Akademia Park in Kisarazu, Japan,August 25–29, 2003. approximately 450 contributors and site visitors attended,with 330 from Japan and one zero one from 34 different nations.
There are 3 significant different types of human retroviruses, specifically HIV, HTLV, and endogenous human retroviruses. This e-book offers the newest findings at the replication of those human retroviruses. This booklet is exclusive in that there was no related booklet that integrates the findings from the 3 recognized periods of human retroviruses.
Considering seriously approximately examine and information research Beins and McCarthy current a continuing advent to stats and learn equipment, making a choice on diverse examine components and the way one techniques them statistically. The textual content is designed for a one- or two-semester mixed path in records and study Methods/Experimental Psychology.
Even though age has been well-known as a threat issue for late-onset dementia of Alzheimer style, its etiology is unknown as but. numerous age-related metabolic abnormalities might therefore develop into vital for the pathogenesis of the late-onset shape. experiences on the cellular/molecular point in mind tissue are attainable submit mortem, yet lack info at the starting of the sickness.
- The Operations Research Problem Solver
- Gene Technology: Stem Cell and Leukemia Research
- Lethal Yellowing: Research and Practical Aspects
- Advanced Research on Animal Cell Technology
- Case Based Reasoning : Research Paradigm
Additional info for Cell and Animal Models in Aging and Dementia Research
Proc Natl Acad Sci USA 85: 9811-9815 Mullan M, Crawford F, Axelman K, Houlden H, Lilius L, Winblad B, Lannfelt L (1992) A pathogenic mutation of probable Alzheimer's disease in the APP gene at the N-terminus of ~-amyloid. Nature Genet 1: 345-347 Murrell J, Farlow M, Ghetti B, Benson MD (1991) A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science 254: 97-99 Nakamura K, Wu G, Ledeen RW (1992) Protection of neuro-2a cells against calcium ionophore cytotoxicity by gangliosides.
1 Neurosci Res 25: 360-368 10hnson GV, Litersky 1M, lope RS (1991) Degradation of microtubule-associated protein 2 and brain spectrin by calpain: a comparative study. 1 Neurochem 56: 1630-1638 Kalaria RN, Harik SI (1989) Reduced glucose transporter at the blood-brain barrier and in cerebral cortex in Alzheimer's disease. 1 Neurochem 53: 1083-1088 Kang 1, Lemaire H-G, Unterbeck A, Salbaum 1M, Masters CL, Grzesckik K-H, Multhaup G, Beyreuther K, Muller-Hill B (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.
From the Kentucky Research Foundation. References Abe K, Tanzi RE, Kogure K (1991) Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex. Neurosci Lett 125: 172-174 Andorn AC, Britton RS, Bacon RR (1990) Evidence that lipid peroxidation and total iron are increased in Alzheimer's brain. Neurobiol Aging 11: 316 40 V. L. Smith-Swintosky and M. P. Mattson Araki W, Kitaguchi N, Tokushima Y, Ishii K, Aratake H, Shimohana S, Nakamura S, Kimura J (1991) Trophic effects of ~-amyloid precursor protein on cerebral cortical neurons in culture.
Cell and Animal Models in Aging and Dementia Research by H. Oberpichler-Schwenk (auth.), Prof. Dr. S. Hoyer, Dr. D. Müller, Dr. K. Plaschke (eds.)