
By H. Oberpichler-Schwenk (auth.), Prof. Dr. S. Hoyer, Dr. D. Müller, Dr. K. Plaschke (eds.)
ISBN-10: 3211825495
ISBN-13: 9783211825495
ISBN-10: 3709193508
ISBN-13: 9783709193501
Although age has been well-known as a threat issue for late-onset dementia of Alzheimer sort, its etiology is unknown as but. a number of age-related metabolic abnormalities may perhaps hence turn into very important for the pathogenesis of the late-onset shape. reports on the cellular/molecular point in mind tissue are attainable submit mortem, yet lack details at the starting of the illness. during this complement, diverse methods are handled how you can set off structural and/or metabolic abnormalities in appropriate cellphone cultures, in mind slices and in experimental animals, and the way behavioral adjustments parallel the metabolic variations.
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Additional info for Cell and Animal Models in Aging and Dementia Research
Example text
Proc Natl Acad Sci USA 85: 9811-9815 Mullan M, Crawford F, Axelman K, Houlden H, Lilius L, Winblad B, Lannfelt L (1992) A pathogenic mutation of probable Alzheimer's disease in the APP gene at the N-terminus of ~-amyloid. Nature Genet 1: 345-347 Murrell J, Farlow M, Ghetti B, Benson MD (1991) A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science 254: 97-99 Nakamura K, Wu G, Ledeen RW (1992) Protection of neuro-2a cells against calcium ionophore cytotoxicity by gangliosides.
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Cell and Animal Models in Aging and Dementia Research by H. Oberpichler-Schwenk (auth.), Prof. Dr. S. Hoyer, Dr. D. Müller, Dr. K. Plaschke (eds.)
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