New PDF release: Cell and Animal Models in Aging and Dementia Research

By H. Oberpichler-Schwenk (auth.), Prof. Dr. S. Hoyer, Dr. D. Müller, Dr. K. Plaschke (eds.)

ISBN-10: 3211825495

ISBN-13: 9783211825495

ISBN-10: 3709193508

ISBN-13: 9783709193501

Although age has been well-known as a threat issue for late-onset dementia of Alzheimer sort, its etiology is unknown as but. a number of age-related metabolic abnormalities may perhaps hence turn into very important for the pathogenesis of the late-onset shape. reports on the cellular/molecular point in mind tissue are attainable submit mortem, yet lack details at the starting of the illness. during this complement, diverse methods are handled how you can set off structural and/or metabolic abnormalities in appropriate cellphone cultures, in mind slices and in experimental animals, and the way behavioral adjustments parallel the metabolic variations.

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Download e-book for iPad: Cell and Animal Models in Aging and Dementia Research by H. Oberpichler-Schwenk (auth.), Prof. Dr. S. Hoyer, Dr. D.

Even though age has been well-known as a threat issue for late-onset dementia of Alzheimer style, its etiology is unknown as but. numerous age-related metabolic abnormalities might therefore develop into vital for the pathogenesis of the late-onset shape. experiences on the cellular/molecular point in mind tissue are attainable submit mortem, yet lack info at the starting of the sickness.

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Proc Natl Acad Sci USA 85: 9811-9815 Mullan M, Crawford F, Axelman K, Houlden H, Lilius L, Winblad B, Lannfelt L (1992) A pathogenic mutation of probable Alzheimer's disease in the APP gene at the N-terminus of ~-amyloid. Nature Genet 1: 345-347 Murrell J, Farlow M, Ghetti B, Benson MD (1991) A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science 254: 97-99 Nakamura K, Wu G, Ledeen RW (1992) Protection of neuro-2a cells against calcium ionophore cytotoxicity by gangliosides.

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From the Kentucky Research Foundation. References Abe K, Tanzi RE, Kogure K (1991) Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex. Neurosci Lett 125: 172-174 Andorn AC, Britton RS, Bacon RR (1990) Evidence that lipid peroxidation and total iron are increased in Alzheimer's brain. Neurobiol Aging 11: 316 40 V. L. Smith-Swintosky and M. P. Mattson Araki W, Kitaguchi N, Tokushima Y, Ishii K, Aratake H, Shimohana S, Nakamura S, Kimura J (1991) Trophic effects of ~-amyloid precursor protein on cerebral cortical neurons in culture.

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Cell and Animal Models in Aging and Dementia Research by H. Oberpichler-Schwenk (auth.), Prof. Dr. S. Hoyer, Dr. D. Müller, Dr. K. Plaschke (eds.)


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