Klaus Ebnet's Cell Polarity 1: Biological Role and Basic Mechanisms PDF

By Klaus Ebnet

ISBN-10: 3319144626

ISBN-13: 9783319144627

ISBN-10: 3319144634

ISBN-13: 9783319144634

This paintings presents a state-of-the artwork evaluate at the so much correct points of phone polarity.

Volume 1 addresses mobile polarity and telephone migration (front-rear polarity), telephone polarity and barrier formation (apico-basal polarity) and neuronal polarity. It really makes a speciality of mobilephone polarity on the molecular point and the underlying molecular mechanisms. It additionally elaborates the typical ideas and mechanisms that keep watch over mobile polarization in several phone forms and contexts.

Both volumes are meant for professors, staff leaders and researchers in phone biology in addition to doctors within the fields of anatomy, cellphone biology, body structure, pathology and tumor biology.

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Extra info for Cell Polarity 1: Biological Role and Basic Mechanisms

Example text

This was shown first in Drosophila follicle epithelial cells and stage 7 oocyte (Benton and St Johnston 2003), and recently suggested in C. elegans embryo (Motegi et al. 2011), but not been fully validated in mammalian cells. Importantly, the role of PAR-5, one of the other PAR components, is to support these antagonistic interactions between the aPKC complex and PAR-1(Fig. 1a) (Benton and St Johnston 2003; Suzuki et al. 2004). In general, PAR-5, which corresponds to the mammalian 14-3-3 proteins, recognizes serine/threonine-phosphorylated residues within the consensus RXXpS/TXP or RXXXpS/TXP (X represents any amino acid) sequence and affects functions and/or localization of target proteins (Tzivion et al.

Nat Rev Mol Cell Biol 2(4):285–293. 1038/35067088 Wieschaus E, Nu¨sslein-Volhard C, Ju¨rgens G (1984) Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. III. Zygotic loci on the X-chromosome and fourth chromosome. Roux Arch Dev Biol 193(5):296–307. 1007/BF00848158 1 The PAR3-aPKC-PAR6 Complex 23 Wirtz-Peitz F, Nishimura T, Knoblich JA (2008) Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization. Cell 135(1):161–173 Wodarz A, Hinz U, Engelbert M, Knust E (1995) Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila.

Curr Biol 11(2):75–87 Daley WP, Gervais EM, Centanni SW, Gulfo KM, Nelson DA, Larsen M (2012) ROCK1-directed basement membrane positioning coordinates epithelial tissue polarity. Development 139(2): 411–422. 075366 Dequiedt F, Martin M, Von Blume J, Vertommen D, Lecomte E, Mari N, Heinen MF, Bachmann M, Twizere JC, Huang MC, Rider MH, Piwnica-Worms H, Seufferlein T, Kettmann R (2006) New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases.

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Cell Polarity 1: Biological Role and Basic Mechanisms by Klaus Ebnet

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