By Wayne F. Robinson, Clive R. R. Huxtable
Written for veterinary undergraduates, this finished textual content explores the usually obscured hyperlink among illness on the mobilephone and tissue point, and that encountered by way of the operating clinician. in accordance with a path taught via the editors, the booklet makes an attempt to strike a stability among the desires of the scholar and expert wisdom. each one bankruptcy explains styles of illness specifically organs and relates them to either the pathophysiologic alterations and the outward visual appeal of the ailing animal.
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Extra info for Clinicopathologic Principles for Veterinary Medicine
In addition to causing extensive lymphoid damage, some viruses, for example BVD virtus, may also exert generalized immunosuppressive effects through the stimulation of interferon production. Viruses may also impair immune function when they infect accessory cells such as neutrophils and macrophages and cause defective leukocyte degranulation and phagocytosis. Secondary bacterial invasion is a usual sequel to virusinduced immunosuppression. Immunosuppression may also accompany infections with other agents including parasites such as Demodex, Toxoplasma, Trypanosoma and Trichinella.
A similar mechanism can account for the destruction of circulating cells in infectious diseases in which modifying antigens are shed by microorganisms. This is exemplified by Salmonella infections in which precocious destruction of red blood cells is a feature. Finally, this mechanism is the basis of the damage wrought in certain forms of autoimmune disease such as autoimmune hemolytic anemia. 7. Clinical type II hypersensitivities 1 Isoimmune reactions Neonatal hemolytic anemia Incompatible blood transfusion 2 Drug-induced cytotoxicty Red cell modifying Penicillin Quinine L-Dopafl Aminosalicylic acid Phenacetin Granulocyte modifying Sulfonamides Phenylbutazone Aminopyrine Phenathiazine Chloramphenicol Platelet modifying Phenylbutazone Quinine Apronalide Sulfonamides Chloramphenicol 3 Infectious diseases Salmonellosis (particularly avian) Equine infectious anemia virus Aleutian disease virus Anaplasmosis Trypanosomiasis 4 Autoimmune diseases Autoimmune hemolytic anemia Idiopathic thrombocytopenia Automimmune glomerulonephritis (Goodpasture's syndrome) a 29 Two main types of immune complex disease are recognized: local and systemic.
Classification of lymphoid tumors Neoplasms of the lymphoid system have traditionally been grouped into two classes: leukemias and lymphomas. In leukemia, neoplastic leukocytes predominate in the circulation, whereas lymphomas are confined largely to lymphoid organs. Several forms of these two major divisions are distinguished by the type of cell from which the clone arose, the properties of the neoplastic cells and the clinical signs accompanying the disease (see also Chapter 3). These various subtypes are identified by their possession of different cell surface and enzyme markers.
Clinicopathologic Principles for Veterinary Medicine by Wayne F. Robinson, Clive R. R. Huxtable