By Balwinder, M.D. Singh
Disseminated Intravascular Coagulation is a devastating syndrome characterised through the systemic activation of frequent activation of the coagulation cascade and thrombosis, which could lead to critical bleeding and should result in organ failure. contemporary experiences have proven that the occurrence of DIC is lowering, specifically in males. regardless of the advancements in future health care supply, the morbidity and mortality as a result of DIC is still very excessive. Early prognosis and exact analysis are vital in bettering the results of sufferers with DIC. even if, there's a loss of a optimal diagnostic try out to diagnose DIC and there's a shortage of remedy or administration ideas. accordingly, an figuring out of the pathophysiology, skill to diagnose the DIC syndrome and to regard early, is the foremost. This booklet offers an enormous well timed replace at the medical manifestations, vital possibility components, and therapy options for DIC, and gives in-depth info on pathophysiological facets and numerous diagnostic rankings used to diagnose DIC. additionally, we involved in yes very important elements on the topic of DIC comparable to Sepsis, continual DIC in melanoma sufferers, coagulopathy of liver problems vs DIC, and DIC in urological malignancies. furthermore, this e-book presents proof from an enormous research picking out the predictors influencing the health facility mortality charges of the significantly in poor health sufferers with DIC. This e-book deals a large scope of data for physicians in all fields, whether or not they are intensivists, basic care physicians or oncologists, it will be a huge resource for picking out the DIC syndrome early, and the fitting steps to enhance sufferer results should be taken faster.
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Extra info for Disseminated Intravascular Coagulation (DIC) Clinical Manifestations, Diagnosis and Treatment Options
DIC complicating a case of trauma is usually responsible for late morbidity. Trauma patients with systemic inflammatory response syndrome [SIRS] are at higher risk, with more than 50 % of these patients developing DIC [24, 42- 43]. Trauma patients with head injury and extensive transfusion are also at increased risk of developing DIC. The evidence relating head injury and consumption coagulopathy started emerging in the year 1974, when Goodnight et al.  and Strinchini et al.  in two Risk Factors for Disseminated Intravascular Coagulation 25 different studies demonstrated defibrination in cases of head injury.
So, the initiating factor is usually endo or exotoxin originating from the organism, with the most important mechanism being the activation of extrinsic pathway mediated by 22 Akhilesh Kumar Tiwari, Rajiv Ratan Singh, Rishi Raj Sanjay et al. the interaction of tissue factor following endothelial damage. These bacterial endotoxins have also been associated with the activation of the intrinsic pathway mediated by factor XII . Gram negative bacteria are one of the most common, but, not the only organisms responsible for the DIC in sepsis.
Aortic aneurysm-induced disseminated intravascular coagulation. Ann Vasc Surg 1996;10:396-405.. , Jr Purification, characterization, and fibrinogen cleavage sites of three fibrinolytic enzymes from the venom of Crotalus basiliscus basiliscus. Biochemistry. 1992;31:4547–4557.  Retzios AD, Markland FS. Fibrinolytic enzymes from the venoms of Agkistrodon contortrix contortrix and Crotalus basiliscus basiliscus: cleavage site specificity towards the alpha-chain of fibrin. Thromb Res. 1994;74:355–367  Singletary EM, Rochman AS, Bodmer JC, Holstege CP.
Disseminated Intravascular Coagulation (DIC) Clinical Manifestations, Diagnosis and Treatment Options by Balwinder, M.D. Singh