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Additional resources for Understanding leukemias, lymphomas, and myelomas

Sample text

1). It is of interest that there is an almost identical amount of hematopoietic marrow in the infant and adult despite an almost fivefold disparity in body weight. As the child gets older, much of the marrow space is filled with fat cells. hematopoiesis, stem cells, and progenitor cells To the naked eye, bone marrow looks like jelly, but under the microscope it can be seen to be interspersed with cells that will eventually become blood cells, all in various stages of development. Although mature red blood cells, white blood cells, and platelets are also present in the marrow, the most important marrow cells are stem cells, the parents and grandparents of blood cells (Fig.

5 B-cell lymphocyte and the corresponding malignancy arising in accordance with the degree of cell maturation. suggesting cure of high-grade lymphoma with such drugs were made by Vincent DeVita and his colleagues in 1975, in Bethesda, Maryland, USA. During the past two decades the enormous advances in the understanding of the immune system have paved the way towards an enhanced understanding of many of the lymphoid malignancies. The great heterogeneity of this group of diseases continues to be challenging and our increased understanding of the molecular abnormalities associated with each type has led to more tailored and more successful therapies, such as the monoclonal antibodies directed against specific targets, for example, rituximab (Rituxan, Mabthera) and the application of stem cell transplants.

Platelets are therefore vital in the maintenance of small blood vessels, and spontaneous bleeding may occur if there are too few of them. Normally, there are about 150 to 400 × 109/L platelets in the blood. Unlike many other cells in the body, the population of blood cells is not fixed; blood cells are released from the bone marrow into the blood, where they circulate until they die. It is therefore remarkable that despite the fact that the population or, indeed, concentration of cells in the blood varies widely, the values observed in normal individuals are remarkably consistent, particularly considering the vast differences in the life spans of these cells.

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